[Suppressive action of the influenza virus on the bone marrow stem cells of mice].
Identifieur interne : 002D86 ( Main/Exploration ); précédent : 002D85; suivant : 002D87[Suppressive action of the influenza virus on the bone marrow stem cells of mice].
Auteurs : V F Semenkov ; V F Lavrov ; L P KhodakovaSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Activation virale (effets des radiations), Animaux, Cellules souches hématopoïétiques (effets des radiations), Cellules souches hématopoïétiques (immunologie), Femelle, Moelle osseuse (effets des radiations), Moelle osseuse (immunologie), Numération cellulaire, Souris, Souris de lignée C57BL, Souris de lignée CBA, Température élevée, Test clonogénique, Tolérance immunitaire, Transplantation de cellules souches hématopoïétiques, Transplantation de moelle osseuse, Virus de la grippe A (effets des radiations), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- effets des radiations : Activation virale, Cellules souches hématopoïétiques, Moelle osseuse, Virus de la grippe A.
- immunologie : Cellules souches hématopoïétiques, Moelle osseuse, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- Animaux, Femelle, Numération cellulaire, Souris, Souris de lignée C57BL, Souris de lignée CBA, Température élevée, Test clonogénique, Tolérance immunitaire, Transplantation de cellules souches hématopoïétiques, Transplantation de moelle osseuse.
English descriptors
- KwdEn :
- Animals, Bone Marrow (immunology), Bone Marrow (radiation effects), Bone Marrow Transplantation, Cell Count, Colony-Forming Units Assay, Female, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells (immunology), Hematopoietic Stem Cells (radiation effects), Hot Temperature, Immune Tolerance, Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza A virus (radiation effects), Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Virus Activation (radiation effects).
- MESH :
- immunology : Bone Marrow, Hematopoietic Stem Cells, Influenza A virus.
- pathogenicity : Influenza A virus.
- radiation effects : Bone Marrow, Hematopoietic Stem Cells, Influenza A virus, Virus Activation.
- Animals, Bone Marrow Transplantation, Cell Count, Colony-Forming Units Assay, Female, Hematopoietic Stem Cell Transplantation, Hot Temperature, Immune Tolerance, Mice, Mice, Inbred C57BL, Mice, Inbred CBA.
Abstract
The effect of pathogenic and noninfectious influenza viruses with different surface antigens on colony-forming stem cells of (CBA X C57BL/6)F1 mice was studied. Bone marrow cells were infected with A/PR8/34 (H1N1)/A/Krasnodar/101/59 (H2N2) viruses, a recombinant A/PK-6-3 (H2N1) strain thereof, A/Khabarovsk/933/77 (H1N1) strain; then they were inoculated intravenously to irradiated (820 rad) syngeneic recipients, and colony-forming units (CFU) were determined in the spleens 9 days after injection. Inoculation of bone marrow cells (2 X 10(5) per mouse) to the irradiated recipients immediately after mixing with a live A/Krasnodar virus heated at 56 degrees C, live A/PK-6-3, and A/Khabarovsk viruses resulted in suppression of formation of CFU and marked atrophy of the recipients' spleens. There was no suppression after the use in these experiments of the pathogenic A/PR/8/34 strain. Inhibition of CFU production in the spleen was observed after inoculation of the recipients with bone marrow cells incubated for 1 hour at 37 degrees C with A/PR/8/34, A/Krasnodar/101/59 viruses and the recombinant strain. Possible mechanisms of the suppressive effect of influenza A virus on CFU production in mice are discussed.
PubMed: 2904194
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Suppressive action of the influenza virus on the bone marrow stem cells of mice].</title><author><name sortKey="Semenkov, V F" sort="Semenkov, V F" uniqKey="Semenkov V" first="V F" last="Semenkov">V F Semenkov</name></author><author><name sortKey="Lavrov, V F" sort="Lavrov, V F" uniqKey="Lavrov V" first="V F" last="Lavrov">V F Lavrov</name></author><author><name sortKey="Khodakova, L P" sort="Khodakova, L P" uniqKey="Khodakova L" first="L P" last="Khodakova">L P Khodakova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1988 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:2904194</idno><idno type="pmid">2904194</idno><idno type="wicri:Area/PubMed/Corpus">000473</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000473</idno><idno type="wicri:Area/PubMed/Curation">000473</idno><idno 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last="Lavrov">V F Lavrov</name></author><author><name sortKey="Khodakova, L P" sort="Khodakova, L P" uniqKey="Khodakova L" first="L P" last="Khodakova">L P Khodakova</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Marrow (immunology)</term><term>Bone Marrow (radiation effects)</term><term>Bone Marrow Transplantation</term><term>Cell Count</term><term>Colony-Forming Units Assay</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Hematopoietic Stem Cells (immunology)</term><term>Hematopoietic Stem Cells (radiation effects)</term><term>Hot Temperature</term><term>Immune Tolerance</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza A virus (radiation effects)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred CBA</term><term>Virus Activation (radiation effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation virale (effets des radiations)</term><term>Animaux</term><term>Cellules souches hématopoïétiques (effets des radiations)</term><term>Cellules souches hématopoïétiques (immunologie)</term><term>Femelle</term><term>Moelle osseuse (effets des radiations)</term><term>Moelle osseuse (immunologie)</term><term>Numération cellulaire</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris de lignée CBA</term><term>Température élevée</term><term>Test clonogénique</term><term>Tolérance immunitaire</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Transplantation de moelle osseuse</term><term>Virus de la grippe A (effets des radiations)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Activation virale</term><term>Cellules souches hématopoïétiques</term><term>Moelle osseuse</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules souches hématopoïétiques</term><term>Moelle osseuse</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bone Marrow</term><term>Hematopoietic Stem Cells</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Bone Marrow</term><term>Hematopoietic Stem Cells</term><term>Influenza A virus</term><term>Virus Activation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bone Marrow Transplantation</term><term>Cell Count</term><term>Colony-Forming Units Assay</term><term>Female</term><term>Hematopoietic Stem Cell Transplantation</term><term>Hot Temperature</term><term>Immune Tolerance</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Inbred CBA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Numération cellulaire</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris de lignée CBA</term><term>Température élevée</term><term>Test clonogénique</term><term>Tolérance immunitaire</term><term>Transplantation de cellules souches hématopoïétiques</term><term>Transplantation de moelle osseuse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of pathogenic and noninfectious influenza viruses with different surface antigens on colony-forming stem cells of (CBA X C57BL/6)F1 mice was studied. Bone marrow cells were infected with A/PR8/34 (H1N1)/A/Krasnodar/101/59 (H2N2) viruses, a recombinant A/PK-6-3 (H2N1) strain thereof, A/Khabarovsk/933/77 (H1N1) strain; then they were inoculated intravenously to irradiated (820 rad) syngeneic recipients, and colony-forming units (CFU) were determined in the spleens 9 days after injection. Inoculation of bone marrow cells (2 X 10(5) per mouse) to the irradiated recipients immediately after mixing with a live A/Krasnodar virus heated at 56 degrees C, live A/PK-6-3, and A/Khabarovsk viruses resulted in suppression of formation of CFU and marked atrophy of the recipients' spleens. There was no suppression after the use in these experiments of the pathogenic A/PR/8/34 strain. Inhibition of CFU production in the spleen was observed after inoculation of the recipients with bone marrow cells incubated for 1 hour at 37 degrees C with A/PR/8/34, A/Krasnodar/101/59 viruses and the recombinant strain. Possible mechanisms of the suppressive effect of influenza A virus on CFU production in mice are discussed.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Khodakova, L P" sort="Khodakova, L P" uniqKey="Khodakova L" first="L P" last="Khodakova">L P Khodakova</name><name sortKey="Lavrov, V F" sort="Lavrov, V F" uniqKey="Lavrov V" first="V F" last="Lavrov">V F Lavrov</name><name sortKey="Semenkov, V F" sort="Semenkov, V F" uniqKey="Semenkov V" first="V F" last="Semenkov">V F Semenkov</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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